(R)-(-)-PK 11195

• CAT Number: I047627
• CAS Number: 205934-46-9
• Molecular Formula: C21H21ClN2O
• Molecular Weight: 352.86
• Purity: ≥95%
• IUPAC Name: N-[(2S)-butan-2-yl]-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
• InChI: InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3/t14-/m0/s1
• SMILES: CC[C@H](C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl

(R)-enantiomer of PK 11195 (Axon 1208), a peripheral benzodiazepine antagonist. It is a drug reference standard of [11C](R)-PK 11195 that is used for PET study.
Radioligand precursors N-Desmethyl-PK 11195 (Axon 2833) and (R)-(-)-N-Desmethyl-PK 11195 (Axon 2784) are also available.
KEYWORDS: (R)-(-)-PK 11195 | BZD antagonist | supplier | (R)-(-)-PK11195 | (R)-(-)-PK-11195 | CAS [205934-46-9] | GABA | GABA-A | Antagonist | Ion Channels

Reference

F Shah et al. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol. 1994 May;21(4):573-81.