(R)-Pramipexole-d3 Dihydrochloride

• CAT Number: C000494
• CAS Number: 1432230-09-5
• Molecular Formula: C₁₀H₁₄D₃N₃S • 2(HCl)
• Purity: ≥95%
• Synonyms: (R)-4,5,6,7-Tetrahydro-N6-(propyl-d3)-2,6-benzothiazolediamine Dihydrochloride
• Solubility: Methanol (Slightly, Sonicated, Heated), Water (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C, Inert atmosphere

(R)-Pramipexole-d3 Dihydrochloride,(CAT: C000494) holds significance in the realm of pharmaceutical chemistry and neuroscience. It is a deuterated form of the (R)-Pramipexole enantiomer, which serves as a dopamine D2 receptor agonist. This compound’s action as a dopamine agonist underscores its relevance in the treatment of Parkinson’s disease and related conditions, where it aids in managing motor symptoms. The deuterated form, (R)-Pramipexole-d3 Dihydrochloride, can be used in pharmacokinetic studies and tracer studies to understand drug metabolism and distribution.

Reference

Mierau, J., et al.: J. Med. Chem., 30, 494 (1987), Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)