(R)-(-)-Rolipram

• CAT Number: I005130
• CAS Number: 85416-75-7
• Molecular Formula: C16H21NO3
• Molecular Weight: 275.34
• Purity: ≥95%
• Target: Phosphodiesterase (PDE)
• Solubility: DMSO: ≥ 49 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
• InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
• InChIKey: HJORMJIFDVBMOB-LBPRGKRZSA-N
• SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

(R)-(-)-Rolipram (Cat No.:I005130) is a cAMP-specific PDE4 inhibitor with IC50 of 220nM. In the inhibition of PDE4 membrane binding experiment, its inhibitory effect is 2.5 times higher than that of (+)-rolipram. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Souness JE, et al. Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase. Biochem J. 1993 Apr 15;291 ( Pt 2):389-95.
[2]. Ohsawa F, et al. Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn J Pharmacol. 1998 Jun;77(2):147-54.