(R)-SCH 42495

• CAT Number: I016695
• CAS Number: 156792-25-5
• Molecular Formula: C₂₀H₂₉NO₄S₂
• Molecular Weight: 411.58
• Purity: ≥95%
• IUPAC Name: ethyl (2S)-2-[[(2R)-2-(acetylsulfanylmethyl)-3-(2-methylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate
• InChI: InChI=1S/C20H29NO4S2/c1-5-25-20(24)18(10-11-26-4)21-19(23)17(13-27-15(3)22)12-16-9-7-6-8-14(16)2/h6-9,17-18H,5,10-13H2,1-4H3,(H,21,23)/t17-,18-/m0/s1
• InChIKey: ZVQXPUMRSJGLSF-ROUUACIJSA-N
• SMILES: CCOC(=O)[C@H](CCSC)NC(=O)[C@@H](CC1=CC=CC=C1C)CSC(=O)C

(R)-SCH 42495(CAT: I016695) is the less active enantiomer of SCH 42495, an orally active neutral metalloendopeptidase (NEP) inhibitor with demonstrated antihypertensive effects. As the ethyl ester prodrug of SCH 42354, it inhibits NEP, a key enzyme responsible for degrading atrial natriuretic factors (ANFs) in vitro. This inhibition enhances vasodilatory and natriuretic responses, making it particularly valuable in cardiovascular research. Studies on (R)-SCH 42495 and its active counterparts provide insights into NEP’s role in regulating blood pressure and fluid homeostasis, supporting the development of therapeutic strategies for hypertension and related cardiovascular disorders.