R-SKF-38393A HCl

• CAT Number: I035755
• CAS Number: 81702-42-3
• Molecular Formula: C16H18ClNO2
• Molecular Weight: 291.77
• Purity: 98%
• Synonyms: R(+)-SKF-38393A; R(+) SKF 38393A; R(+)SKF38393A; R-SKF-38393A; R SKF 38393A; RSKF38393A
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;hydrochloride
• InChI: InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• InChIKey: YEWHJCLOUYPAOH-PFEQFJNWSA-N
• SMILES: C1CNC[C@@H](C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

R-SKF-38393A hydrochloride（Cat No.:I035755）is a selective dopamine D1 receptor agonist used primarily in research to study the role of dopamine in the central nervous system. It acts by selectively activating D1 receptors, which are involved in regulating motor control, cognition, and mood. R-SKF-38393A has been studied for its potential applications in understanding neuropsychiatric disorders such as Parkinson’s disease, schizophrenia, and ADHD. It can also serve as a tool for exploring the neurobiological mechanisms underlying dopamine-related diseases. However, its clinical applications are limited, and it remains primarily a research compound.

Reference

1: Jiang H, Jackson-Lewis V, Muthane U, Dollison A, Ferreira M, Espinosa A, Parsons B, Przedborski S. Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats. Brain Res. 1993 Jun 11;613(2):347-51. PubMed PMID: 8186990.