CONTACT US
Home > Inhibitors/Agonists> > (R)-TTBK1-IN-1
2735015-59-3-(R)-TTBK1-IN-1 (R)-TTBK1-IN-1

(R)-TTBK1-IN-1

For research use only. Not for therapeutic Use.

  • CAT Number: I041799
  • CAS Number: 2735015-59-3
  • Molecular Formula: C18H19N5O2
  • Molecular Weight: 337.38
  • Purity: ≥95%
Inquiry Now
Related Small Molecules: Torcetrapib     (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide     N-Acetyl-L-arginine dihydrate    

(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1]. (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.


Catalog Number I041799
CAS Number 2735015-59-3
Synonyms

(3R)-1-[1-(2-amino-6-methoxypyrimidin-4-yl)pyrrolo[3,2-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol

Molecular Formula C18H19N5O2
Purity ≥95%
InChI InChI=1S/C18H19N5O2/c1-4-18(2,24)7-5-13-9-14-12(11-20-13)6-8-23(14)15-10-16(25-3)22-17(19)21-15/h6,8-11,24H,4H2,1-3H3,(H2,19,21,22)/t18-/m1/s1
InChIKey HPJVZSVEIGCFJP-GOSISDBHSA-N
SMILES CCC(C)(C#CC1=CC2=C(C=CN2C3=CC(=NC(=N3)N)OC)C=N1)O
Reference

[1]. Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380.
 [Content Brief]

Request a Quote