For research use only. Not for therapeutic Use.
(R)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R[1].
(R)-V-0219 (0.1 nM) hydrochloride is capable to activate calcium fluxes in HEK cells stably expressing hGLP-1R, and induces the receptor activation stimulated by GLP-1 with an EC50 value of 10 nM[1].
| Catalog Number | I041376 |
| Synonyms | 4-[[(3R)-1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]piperidin-3-yl]methyl]morpholine;hydrochloride |
| Molecular Formula | C20H26ClF3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H25F3N4O2.ClH/c21-20(22,23)17-5-3-16(4-6-17)19-24-18(29-25-19)14-27-7-1-2-15(13-27)12-26-8-10-28-11-9-26;/h3-6,15H,1-2,7-14H2;1H/t15-;/m1./s1 |
| InChIKey | PTRIYHLSBQMDQM-XFULWGLBSA-N |
| SMILES | C1CC(CN(C1)CC2=NC(=NO2)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4.Cl |
| Reference | [1]. Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”. J Med Chem. 2022 Apr 14;65(7):5449-5461. |
