R-(+)-Warfarin

• CAT Number: R013558
• CAS Number: 5543-58-8
• Molecular Formula: C19H16O4
• Molecular Weight: 308.333
• Purity: ≥95%
• Synonyms: 4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one; R-(+)- ?3-(α-Acetonylbenzyl)-4-hydroxycoumarin; (+)-Warfarin; (R)-Warfarin; Dextrowarfarin
• Storage: -20°C
• IUPAC Name: 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]chromen-2-one
• InChI: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m1/s1
• InChIKey: PJVWKTKQMONHTI-OAHLLOKOSA-N
• SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

Warfarin is an anti-<wbr></wbr>coagulant used to prevent heart attacks, strokes, and the formation of blood clots. It interferes with the use of vitamin K in the required carboxylation of several vitamin K-<wbr></wbr>dependent proteins in the clotting cascade, preventing the initiation of clotting. (+)-<wbr></wbr>Warfarin differs from (−)-<wbr></wbr>warfarin by being five times less potent as a vitamin K antagonist. However the two isomers are metabolized in vivo by different pathways and (+)-<wbr></wbr>warfarin has a longer terminal elimination half-<wbr></wbr>life (35-<wbr></wbr>58 hours) than (−)-<wbr></wbr>warfarin (24-<wbr></wbr>33 hours).