(R)-ZINC-3573

• CAT Number: I010151
• CAS Number: 2089389-15-9
• Molecular Formula: C18H21N5
• Molecular Weight: 307.39
• Purity: ≥95%
• Synonyms: (3R)-N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine
• InChI: InChI=1S/C18H21N5/c1-21(2)15-9-11-22(13-15)18-12-16(14-6-4-3-5-7-14)20-17-8-10-19-23(17)18/h3-8,10,12,15H,9,11,13H2,1-2H3/t15-/m1/s1
• InChIKey: XKBSPAZCFAIBJL-OAHLLOKOSA-N
• SMILES: CN(C)C1CCN(C1)C2=CC(=NC3=CC=NN32)C4=CC=CC=C4

(R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch[1].
(R)-ZINC-3573 (0.001 nM-100 μM) promotes β-hexosaminidase degranulation and induces intracellular calcium release in LAD2 mast cells[1].

Reference

[1]. Lansu K, et al. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat Chem Biol. 2017 May;13(5):529-536.
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