R1487 Hydrochloride

• CAT Number: I003587
• CAS Number: 449808-64-4
• Molecular Formula: C19H19ClF2N4O3
• Molecular Weight: 424.83
• Purity: ≥95%
• Target: p38 MAPK; Autophagy
• Solubility: DMSO ≥ 28 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one;hydrochloride
• InChI: InChI=1S/C19H18F2N4O3.ClH/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21;/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24);1H
• InChIKey: RQHSAIGGUWVOBG-UHFFFAOYSA-N
• SMILES: CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC4CCOCC4.Cl

R1487 Hydrochloride（Cat No.:I003587）is a potent inhibitor of interleukin-2-inducible T-cell kinase (ITK), which plays a critical role in T-cell receptor signaling. This compound is widely used in immunology research to study the regulation of immune responses, particularly in T-cell activation and differentiation. By inhibiting ITK, R1487 Hydrochloride offers potential therapeutic implications in treating autoimmune diseases and allergic disorders. It is valuable for exploring the molecular mechanisms underlying T-cell mediated immunity and serves as an important tool in developing novel therapies targeting immune-related diseases.

Reference

[1]. Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.