(R,1R)-Tenofovir amibufenamide

• CAT Number: I042932
• CAS Number: 1571076-37-3
• Molecular Formula: C22H31N6O5P
• Molecular Weight: 490.49
• Purity: ≥95%
• Synonyms: propan-2-yl 2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]-2-methylpropanoate
• InChI: InChI=1S/C22H31N6O5P/c1-15(2)32-21(29)22(4,5)27-34(30,33-17-9-7-6-8-10-17)14-31-16(3)11-28-13-26-18-19(23)24-12-25-20(18)28/h6-10,12-13,15-16H,11,14H2,1-5H3,(H,27,30)(H2,23,24,25)/t16-,34?/m1/s1
• InChIKey: ORHSFGJQGPUCRR-LXAPUOBYSA-N
• SMILES: C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(NC(C)(C)C(=O)OC(C)C)OC3=CC=CC=C3

(R,1R)-Tenofovir amibufenamide（Cat No.:I042932）is a prodrug of tenofovir, designed to enhance the bioavailability and efficacy of the active compound. Tenofovir is an antiretroviral medication used to treat HIV and chronic hepatitis B infections. By modifying the structure, (R,1R)-Tenofovir amibufenamide improves the pharmacokinetic properties, facilitating better absorption and distribution in the body. Once metabolized, it releases tenofovir, which inhibits viral replication by targeting the reverse transcriptase enzyme. This prodrug is currently being investigated to optimize treatment regimens for HIV and hepatitis B, potentially improving patient outcomes.