For research use only. Not for therapeutic Use.
RA190 (Cat No.: I020682) is a bis benzylidene piperidine, a potent, selective, and orally active proteasome ubiquitin receptor RPN13/ADRM1 inhibitor with anticancer activity. RA190 can trigger an endoplasmic reticulum stress response, p53/p21 signaling axis, and autophagy in multiple myeloma cells.
| Catalog Number | I020682 |
| CAS Number | 1617495-03-0 |
| Molecular Formula | C₂₈H₂₃Cl₅N₂O₂ |
| Purity | ≥95% |
| Target | Proteasome |
| Storage | -20°C |
| IUPAC Name | (3Z,5Z)-1-[(2S)-2-amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;hydrochloride |
| InChI | InChI=1S/C28H22Cl4N2O2.ClH/c29-22-8-6-18(12-24(22)31)10-20-15-34(28(36)26(33)14-17-4-2-1-3-5-17)16-21(27(20)35)11-19-7-9-23(30)25(32)13-19;/h1-13,26H,14-16,33H2;1H/b20-10-,21-11-;/t26-;/m0./s1 |
| InChIKey | UMWXLEVUBFNYIK-VCCJZKHWSA-N |
| SMILES | C1C(=CC2=CC(=C(C=C2)Cl)Cl)C(=O)C(=CC3=CC(=C(C=C3)Cl)Cl)CN1C(=O)C(CC4=CC=CC=C4)N.Cl |
| Reference | [1]. Anchoori RK, et al. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24(6):791-805. |
