(Rac)-AZD 6482

• CAT Number: I018265
• CAS Number: 663620-70-0
• Molecular Formula: C₂₂H₂₄N₄O₄
• Molecular Weight: 408.45
• Purity: ≥95%
• Target: Autophagy
• IUPAC Name: 2-[1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid
• InChI: InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)
• InChIKey: IRTDIKMSKMREGO-UHFFFAOYSA-N
• SMILES: CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3C(=O)O)N4CCOCC4

(Rac)-AZD 6482（Cat No.:I018265）is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) beta isoform, playing a crucial role in platelet activation and aggregation. By inhibiting PI3Kβ, it is valuable in cardiovascular research for studying thrombosis and platelet-related disorders. (Rac)-AZD 6482 has shown promise in preclinical studies as an antithrombotic agent with reduced bleeding risk compared to traditional therapies. Additionally, it is being explored for its potential therapeutic effects in cancers that rely on PI3Kβ signaling, offering a targeted approach in oncology research.

Reference

[1]. Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2(5):425-33.