For research use only. Not for therapeutic Use.
rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1].
rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice[1].
rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg−1 (P<0.001)[1].
| Catalog Number | M140988 |
| CAS Number | 123557-91-5 |
| Synonyms | 5,7-ditert-butyl-3-hydroxy-3-(trifluoromethyl)-1-benzofuran-2-one |
| Molecular Formula | C17H21F3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 |
| InChIKey | RVNOANDLZIIFHB-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC2=C(C(=C1)C(C)(C)C)OC(=O)C2(C(F)(F)F)O |
| Reference | [1]. P Malherbe, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol. 2008 Jun;154(4):797-811. |
