(Rac)-BL-918

• CAT Number: I019164
• CAS Number: 2435589-07-2
• Molecular Formula: C₂₃H₁₅F₈N₃OS
• Molecular Weight: 533.44
• Purity: ≥95%
• Target: ULK; Autophagy
• IUPAC Name: 2-[[3,5-bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide
• InChI: InChI=1S/C23H15F8N3OS/c24-15-6-7-18(17(25)11-15)33-20(35)19(12-4-2-1-3-5-12)34-21(36)32-16-9-13(22(26,27)28)8-14(10-16)23(29,30)31/h1-11,19H,(H,33,35)(H2,32,34,36)
• InChIKey: BDBWQANRZRCMMD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C(C(=O)NC2=C(C=C(C=C2)F)F)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

(Rac)-BL-918（Cat No.:I019164） refers to the racemate of BL-918, a compound that demonstrates potent activation of UNC-51-like kinase 1 (ULK1). This activation of ULK1 leads to the induction of cytoprotective autophagy, a cellular process involved in the degradation and recycling of damaged proteins and organelles. The potential application of BL-918 in the treatment of Parkinson’s disease arises from its ability to promote cytoprotective autophagy, which may help mitigate the underlying pathology of the disease.

Reference

[1]. Ouyang L, et al. Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment. J Med Chem. 2018 Apr 12;61(7):2776-2792.