rac-BRD0705

• CAT Number: I047649
• CAS Number: 1597440-03-3
• Molecular Formula: C20H23N3O
• Molecular Weight: 321.42
• Purity: ≥95%
• IUPAC Name: 4-ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one
• InChI: InChI=1S/C20H23N3O/c1-4-20(13-8-6-5-7-9-13)14-12-21-23-18(14)22-15-10-19(2,3)11-16(24)17(15)20/h5-9,12H,4,10-11H2,1-3H3,(H2,21,22,23)
• SMILES: CCC1(C2=C(NC3=C1C(=O)CC(C3)(C)C)NN=C2)C4=CC=CC=C4

GSK3α inhibitor. Racemic mixture of BRD0705 (Axon 2931), the more active enantiomer and its negative control BRD5648 (Axon 3153).
KEYWORDS: rac-BRD0705 | supplier | GSK3α inhibitor | rac-BRD 0705 | rac-BRD-0705 | CAS [1597440-03-3] | Non Selective (Phosphorylation Substrates) | GSK-3 | Inhibitor | Enzymes | AML

Reference

FF Wagner et al. Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431).