rac-CCT 250863

• CAT Number: I010976
• CAS Number: 1364269-06-6
• Molecular Formula: C24H25F3N4O2S
• Molecular Weight: 490.54
• Purity: ≥95%
• Synonyms: 4-[2-Amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]benzamide
• Target: Apoptosis
• Solubility: Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: 4-[2-amino-5-[4-[(dimethylamino)methyl]thiophen-2-yl]pyridin-3-yl]-2-[(Z)-5,5,5-trifluoropent-3-en-2-yl]oxybenzamide
• InChI: InChI=1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-
• InChIKey: LLEOOSLUHRQCHZ-SREVYHEPSA-N
• SMILES: CC(C=CC(F)(F)F)OC1=C(C=CC(=C1)C2=C(N=CC(=C2)C3=CC(=CS3)CN(C)C)N)C(=O)N

rac-CCT 250863(CAT: I010976) is a potent and selective inhibitor of the Hsp90 co-chaperone Cdc37, widely utilized in cancer and molecular chaperone research. By disrupting the interaction between Hsp90 and Cdc37, rac-CCT 250863 impairs the stabilization and activation of client kinases, leading to proteasomal degradation and inhibition of tumor cell proliferation. This compound is particularly valuable for studying oncogenic signaling pathways dependent on Hsp90-Cdc37, including those in prostate and breast cancers. With high specificity and robust pharmacological activity, rac-CCT 250863 is suitable for in vitro and in vivo studies, advancing therapeutic strategies targeting molecular chaperone complexes in cancer.