For research use only. Not for therapeutic Use.
(Rac)-CP-601927 hydrochloride is the racemate of CP-601927. CP-601927 is a nAChR agonist with Ki values 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively[1].
CP-601927 induces significant antidepressant-like effects in mice. CP-601927 could decrease cholinergic signaling as a result of its reduced efficacy or via desensitization of α4β2* nAChRs[1].
| Catalog Number | I044463 |
| CAS Number | 230615-01-7 |
| Synonyms | 4-(trifluoromethyl)-10-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene;hydrochloride |
| Molecular Formula | C12H13ClF3N |
| Purity | ≥95% |
| InChI | InChI=1S/C12H12F3N.ClH/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9;/h1-2,4,7-8,16H,3,5-6H2;1H |
| InChIKey | ZHTWFWUVFSXTNF-UHFFFAOYSA-N |
| SMILES | C1C2CNCC1C3=C2C=CC(=C3)C(F)(F)F.Cl |
| Reference | [1]. Yann S Mineur, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011 Aug;22(4):291-9. |
