For research use only. Not for therapeutic Use.
(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) used for the research of cognition/memory disorders[1].
Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1].
| Catalog Number | I017642 |
| CAS Number | 787623-60-3 |
| Synonyms | 2-(2-methyl-5-oxo-3-phenylpyrrolidin-1-yl)acetamide |
| Molecular Formula | C13H16N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H16N2O2/c1-9-11(10-5-3-2-4-6-10)7-13(17)15(9)8-12(14)16/h2-6,9,11H,7-8H2,1H3,(H2,14,16) |
| InChIKey | ZTGRWYMPQCQTHD-UHFFFAOYSA-N |
| SMILES | CC1C(CC(=O)N1CC(=O)N)C2=CC=CC=C2 |
| Reference | [1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71. |
