rac Lafutidine-d10

• CAT Number: R056497
• CAS Number: 1795136-26-3
• Molecular Formula: C₂₂H₁₉D₁₀N₃O₄S
• Molecular Weight: 441.61
• Purity: ≥95%
• Synonyms: 2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide-d10; Lafutidine-d10; FRG 8813-d10; Laflutidine-d10; Protecadin-d10; Stogar-d10
• Storage: Desiccate at -20C
• IUPAC Name: N-[(Z)-4-[4-[(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)methyl]pyridin-2-yl]oxybut-2-enyl]-2-(furan-2-ylmethylsulfinyl)acetamide
• InChI: InChI=1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-/i1D2,3D2,4D2,11D2,12D2
• InChIKey: KMZQAVXSMUKBPD-QKXIEJTGSA-N
• SMILES: [2H]C1(C(C(N(C(C1([2H])[2H])([2H])[2H])CC2=CC(=NC=C2)OC/C=C\CNC(=O)CS(=O)CC3=CC=CO3)([2H])[2H])([2H])[2H])[2H]

Rac Lafutidine-d10 is a deuterated form of racemic lafutidine, an anti-ulcer medication known for its histamine H2 receptor antagonist activity. The “d10” indicates that the molecule has ten deuterium atoms replacing hydrogen atoms, enhancing its use as a stable internal standard in mass spectrometry. Lafutidine inhibits gastric acid secretion by blocking H2 receptors, thus aiding in the treatment of conditions like peptic ulcers and gastroesophageal reflux disease (GERD). Rac Lafutidine-d10 is employed in pharmacokinetic studies to precisely measure lafutidine levels and investigate its metabolism and therapeutic efficacy in clinical and pharmaceutical research.