For research use only. Not for therapeutic Use.
(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].
Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].
| Catalog Number | I045652 |
| CAS Number | 61890-25-3 |
| Synonyms | 1-phenyl-2-pyridin-2-ylethanamine |
| Molecular Formula | C13H14N2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H14N2/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12/h1-9,13H,10,14H2 |
| InChIKey | FWUQWDCOOWEXRY-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(CC2=CC=CC=N2)N |
| Reference | [1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85. |
