rac-Modipafant

• CAT Number: R055895
• CAS Number: 122956-68-7
• Molecular Formula: C34H29ClN6O3
• Molecular Weight: 605.095
• Purity: ≥95%
• Synonyms: 4-(2-Chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester; UK 74505
• Target: Dengue virus
• Storage: -20°C
• IUPAC Name: ethyl 4-(2-chlorophenyl)-6-methyl-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate
• InChI: InChI=1S/C34H29ClN6O3/c1-4-44-34(43)31-30(24-9-5-6-10-25(24)35)29(33(42)40-28-11-7-8-17-37-28)20(2)38-32(31)22-12-14-23(15-13-22)41-21(3)39-26-19-36-18-16-27(26)41/h5-19,30,38H,4H2,1-3H3,(H,37,40,42)
• InChIKey: ODRYSCQFUGFOSU-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)NC3=CC=CC=N3)C)C4=CC=C(C=C4)N5C(=NC6=C5C=CN=C6)C

rac-Modipafant is a racemic mixture of a drug originally developed as a potent platelet-activating factor (PAF) receptor antagonist. It was investigated for its potential in treating inflammatory and allergic conditions, such as asthma, by blocking the effects of PAF, a key mediator in inflammation and immune responses. Although clinical development of Modipafant was discontinued, its racemic form remains of interest in research for understanding PAF-related pathways and developing new anti-inflammatory therapies. Its study contributes to the broader exploration of PAF antagonists in medical research.