For research use only. Not for therapeutic Use.
(Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist. (Rac)-PF-998425 has IC50 values of 26 and 90 nM in the AR binding and cellular assays, respectively. (Rac)-PF-998425 has the potential for the research of the androgenetic alopecia[1].
| Catalog Number | I045211 |
| CAS Number | 1076225-26-7 |
| Synonyms | 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)benzonitrile |
| Molecular Formula | C14H14F3NO |
| Purity | ≥95% |
| InChI | InChI=1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2 |
| InChIKey | MENRRRXHFQYXDW-UHFFFAOYSA-N |
| SMILES | C1CCC(C(C1)C2=CC(=C(C=C2)C#N)C(F)(F)F)O |
| Reference | [1]. Li JJ, et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J Med Chem. 2008;51(21):7 |
