rac Timolol-d5 Maleate

• CAT Number: R009859
• CAS Number: 1217260-21-3
• Molecular Formula: C17H28N4O7S
• Molecular Weight: 437.523
• Purity: ≥95%
• Synonyms: 1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (2Z)-2-Butenedioate-d5; (+/-)-Timolol maleate-d5; NSC 312896-d5
• Storage: -20°C
• IUPAC Name: (Z)-but-2-enedioic acid;1-(tert-butylamino)-1,1,2,3,3-pentadeuterio-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
• InChI: InChI=1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/i8D2,9D2,10D
• InChIKey: WLRMANUAADYWEA-RJAXMONVSA-N
• SMILES: CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O

rac Timolol-d5 Maleate is a deuterated form of timolol, a non-selective beta-adrenergic antagonist used to treat glaucoma and hypertension. In this version, five hydrogen atoms are replaced with deuterium, enhancing its utility in pharmacokinetic studies. The “rac” indicates it is a racemic mixture containing both enantiomers of timolol. The maleate salt form improves solubility and stability. The deuterium labeling aids in precise tracking using mass spectrometry and NMR spectroscopy, while the compound retains its therapeutic efficacy for research and clinical applications.