RAF709

For research use only. Not for therapeutic Use.

  • CAT Number: I002108
  • CAS Number: 1628838-42-5
  • Molecular Formula: C28H29F3N4O4
  • Molecular Weight: 542.55
  • Purity: ≥95%
Inquiry Now

<p style=/line-height:25px/>RAF709 is a novel Raf kinase inhibitor extracted from patent WO2014151616A1, compound example 131, has an IC50 of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.<br>IC50 & Target: 0.5 nM (c-Raf), 1.8 nM (b-Raf)[1]<br>InVitro: The invention provides compounds (e.g., RAF709) that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers[1].</p>


Catalog Number I002108
CAS Number 1628838-42-5
Molecular Formula C28H29F3N4O4
Purity ≥95%
Target Raf
Solubility DMSO
Storage Store at -20°C
InChI InChI=1S/C28H29F3N4O4/c1-18-24(15-22(17-32-18)34-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(35-7-11-38-12-8-35)27(33-16-20)39-23-5-9-37-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,34,36)
InChIKey FYNMINFUAIDIFL-UHFFFAOYSA-N
SMILES O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC(C(F)(F)F)=CC=C5
Reference

<p style=/line-height:25px/>
<br>[1]. Robert AVERSA, et al. Biaryl amide compounds as kinase inhibitors. WO2014151616A1.
</p>

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