RAF709

For research use only. Not for therapeutic Use.

  • CAT Number: I002108
  • CAS Number: 1628838-42-5
  • Molecular Formula: C28H29F3N4O4
  • Molecular Weight: 542.55
  • Purity: ≥95%
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RAF709(CAT: I002108) is a potent and selective inhibitor of RAF kinases, including BRAF and CRAF, with high efficacy against mutant BRAF (e.g., BRAF V600E). By targeting the RAF/MEK/ERK pathway, it disrupts tumor proliferation and survival, making it a promising compound in oncology research. RAF709 has shown significant antitumor activity in preclinical models of RAF-driven cancers, offering insights into pathway regulation and resistance mechanisms. Its oral bioavailability and specificity make it a valuable tool for studying RAF kinase biology and developing targeted therapies, particularly for cancers associated with RAF mutations or dysregulated MAPK signaling.


Catalog Number I002108
CAS Number 1628838-42-5
Molecular Formula C28H29F3N4O4
Purity ≥95%
Target Raf
Solubility DMSO
Storage Store at -20°C
IUPAC Name N-[6-methyl-5-[5-morpholin-4-yl-6-(oxan-4-yloxy)pyridin-3-yl]pyridin-3-yl]-3-(trifluoromethyl)benzamide
InChI InChI=1S/C28H29F3N4O4/c1-18-24(15-22(17-32-18)34-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(35-7-11-38-12-8-35)27(33-16-20)39-23-5-9-37-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,34,36)
InChIKey FYNMINFUAIDIFL-UHFFFAOYSA-N
SMILES O=C(NC1=CN=C(C)C(C2=CC(N3CCOCC3)=C(OC4CCOCC4)N=C2)=C1)C5=CC(C(F)(F)F)=CC=C5

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