For research use only. Not for therapeutic Use.
Ramipril（Cat No.:A000717）is an angiotensin-converting enzyme (ACE) inhibitor widely prescribed for managing hypertension, heart failure, and for reducing the risk of cardiovascular events in high-risk patients. By inhibiting ACE, Ramipril decreases the production of angiotensin II, leading to vasodilation, reduced blood pressure, and decreased strain on the heart. Its cardioprotective and renal-protective effects make it beneficial in patients with diabetes or chronic kidney disease. Ramipril’s long-acting profile supports once-daily dosing, enhancing patient adherence. It is a cornerstone in cardiovascular therapy, offering both preventive and therapeutic benefits in hypertension management.
| Catalog Number | A000717 |
| CAS Number | 87333-19-5 |
| Molecular Formula | C23H32N2O5 |
| Purity | ≥95% |
| Target | ACE |
| Solubility | >17.6mg/mL in DMSO |
| Overview of Clinical Research | <span style=”color:#000000;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Ramipril is an ACE inhibitor. The <span style=”orphans: 2; widows: 2;”>Phase-II clinical trials in COVID-2019 infections starts in USA (PO) (NCT04366050).</span></span></span></span> |
| IUPAC Name | (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid |
| InChI | InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1 |
| InChIKey | HDACQVRGBOVJII-JBDAPHQKSA-N |
| SMILES | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O |
| Reference | 1: Omboni S, Malacco E, Mallion JM, Fabrizzi P, Volpe M. Olmesartan vs. ramipril in elderly hypertensive patients: review of data from two published randomized, double-blind studies. High Blood Press Cardiovasc Prev. 2014 Mar;21(1):1-19. doi: 10.1007/s40292-013-0037-9. Epub 2014 Jan 17. Review. PubMed PMID: 24435506.<br /> |
