Ranitidinebismuthcitrate

• CAT Number: M111956
• CAS Number: 128345-62-0
• Molecular Formula: C19H27BiN4O10S
• Molecular Weight: 712.48
• Purity: ≥95%
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: bismuth;1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate
• InChI: InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;;+3/p-3
• InChIKey: XAUTYMZTJWXZHZ-UHFFFAOYSA-K
• SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Bi+3]

Ranitidine Bismuth Citrate（Cat No.:M111956）is a combination medication used to treat ulcers and gastritis, particularly those associated with Helicobacter pylori infection. It combines the H2-receptor antagonist ranitidine, which reduces stomach acid production, with bismuth citrate, which has antibacterial and protective effects on the stomach lining. This dual action helps heal ulcers, prevent their recurrence, and combat H. pylori bacteria. Ranitidine Bismuth Citrate is often used as part of combination therapy with antibiotics to enhance its effectiveness in eradicating H. pylori and promoting long-term gastrointestinal health.

 

Reference

1.McColm, A. A., et al. "Ranitidine bismuth citrate: a novel anti‐ulcer agent with different physico‐chemical characteristics and improved biological activity to a bismuth citrate‐ranitidine admixture." Alimentary pharmacology & therapeutics 10.3 (1996): 241-250.
2.Yuan, Shuofeng, et al. "Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters." Nature microbiology 5.11 (2020): 1439-1448.