For research use only. Not for therapeutic Use.
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.<br>Ranolazine is found to bind more tightly to the inactivated state than the resting state of the sodium channel underlying I(NaL), with apparent dissociation constants K(dr)=7.47 mM and K(di)=1.71 mM, respectively. Ranolazine at 5 mM and 10 mM reversibly shortens the duration of TCs and abolishes the after contraction.<br>Ranolazine significantly and reversibly shortens the action potential duration (APD) of myocytes stimulated at either 0.5 or 0.25 Hz in a concentration-dependent manner in left ventricular myocytes of dogs.
| Catalog Number | A000721 |
| CAS Number | 95635-55-5 |
| Synonyms | CVT 303, RS 43285-003 |
| Molecular Formula | C24H33N3O4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | 3 years -20C powder |
