Ranolazine-d8 dihydrochloride

• CAT Number: S000418
• CAS Number: 1219802-60-4
• Molecular Formula: C24H27D8Cl2N3O4
• Molecular Weight: 508.51
• Purity: ≥95%
• IUPAC Name: N-(2,6-dimethylphenyl)-2-[2,2,3,3,5,5,6,6-octadeuterio-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide;dihydrochloride
• InChI: InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H/i11D2,12D2,13D2,14D2
• InChIKey: RJNSNFZXAZXOFX-ZWKVGDSCSA-N
• SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O.Cl.Cl

Ranolazine-d8 dihydrochloride（Cat No.:S000418） is a deuterated form of ranolazine, where eight hydrogen atoms are replaced with deuterium. This modification enhances the drug’s stability, making it particularly useful for pharmacokinetic and metabolic studies. Ranolazine is an antianginal medication used primarily to treat chronic angina, acting by modulating sodium and calcium channels in cardiac cells, which helps reduce cardiac workload and oxygen consumption. The dihydrochloride form improves solubility and absorption. The deuterated version, Ranolazine-d8 dihydrochloride, allows for a detailed investigation into how the drug metabolizes in the body and its interaction with various biological pathways.