For research use only. Not for therapeutic Use.
Rapamycin（Cat No.:A000450）is a potent inhibitor of the mammalian target of rapamycin (mTOR), a central regulator of cell growth, proliferation, and survival. By inhibiting mTOR complex 1 (mTORC1), rapamycin disrupts key cellular processes, making it a valuable tool in cancer research, immunology, and aging studies. Clinically, rapamycin is used as an immunosuppressant to prevent organ transplant rejection and has shown potential in treating certain cancers and neurodegenerative diseases. It is also being explored for its anti-aging properties due to its ability to modulate metabolic pathways involved in longevity and healthspan.
| Catalog Number | A000450 |
| CAS Number | 53123-88-9 |
| Synonyms | AY 22989；NSC-2260804；Sirolimus；Rapamycin |
| Molecular Formula | C51H79NO13 |
| Purity | ≥95% |
| Target | mTOR |
| Solubility | >45.7mg/mL in DMSO |
| Storage | Desiccate at -20°C |
| Overview of Clinical Research | <span style=”font-family:arial,helvetica,sans-serif;”><span style=”color:#000000;”><span style=”font-size:12px;”>Rapamycin is a <span style=”caret-color: rgb(102, 102, 102); orphans: 2; widows: 2;”>MTOR protein inhibitor and a T lymphocyte inhibitor. It receives the orphan drug status in </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Lymphangioleiomyomatosis and Fibroma. The </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Phase-III clinical trials in Neurofibromatosis 1 (In adults, In children, In the elderly) in Japan (unspecified route) (NCT04461886) started in 2020.</span></span></span></span> |
| IUPAC Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| InChI | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
| InChIKey | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC |
| Reference | <br /> |
