Rapamycin-d3 (contains d0) Technical Grade

• CAT Number: R006524
• CAS Number: 392711-19-2
• Molecular Formula: C51H76D3NO13
• Molecular Weight: 917.2
• Purity: ≥95%
• Synonyms: (-)-Rapamycin-d3; AY 22989-d3; Antibiotic AY 22989-d3; Cypher-d3; NSC 226080-d3; RAPA-d3; RPM-d3; Rapammune-d3; Rapamune-d3; SIIA 9268A-d3; Sirolimus-d3; Wy 090217-d3
• Target: Immunology/Inflammation
• Storage: -20°C
• IUPAC Name: (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19-methoxy-15,17,21,23,29,35-hexamethyl-30-(trideuteriomethoxy)-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• InChI: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11-,16-12-,31-17-,35-25-/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1/i8D3
• InChIKey: QFJCIRLUMZQUOT-NWORAYHKSA-N
• SMILES: [2H]C([2H])([2H])O[C@H]\1C[C@@H]2CC[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H](CC(=O)[C@@H](/C=C(/[C@H]([C@H](C(=O)[C@@H](C[C@@H](/C=C/C=C/C=C1\C)C)C)OC)O)\C)C)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)O)C

Rapamycin-d3 is a deuterated form of rapamycin, a potent immunosuppressant and inhibitor of the mTOR (mechanistic target of rapamycin) pathway. The incorporation of three deuterium atoms into rapamycin enhances its stability and facilitates more accurate tracking in mass spectrometry and NMR studies. This isotopic labeling is useful in pharmacokinetic and pharmacodynamic studies, allowing researchers to monitor drug metabolism, distribution, and interactions within biological systems with greater precision. Rapamycin-d3 is employed in pharmaceutical research to optimize therapeutic strategies and investigate the effects of mTOR inhibition on cellular processes.