Rasagiline

For research use only, not for therapeutic use.

  • CAT Number: I001397
  • CAS Number: 136236-51-6
  • Molecular Formula: C12H13N
  • Molecular Weight: 171.2
  • Purity: ≥95%
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<p style=/line-height:25px/>Rasagiline(AGN1135;TVP1012) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson/’s disease.<br>Target: Monoamine Oxidase (MAO)-B<br>Rasagiline (N-propargyl-1-(R)-aminoindan) is a novel, highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug. Rasagiline is effective as monotherapy or adjunct to L-Dopa for patients with early and late Parkinson/’s disease (PD) [1]. Rasagiline inhibits MAO-B more potently than selegiline and has the advantage of once-daily dosing. In several large, randomized, placebo-controlled trials, rasagiline has demonstrated efficacy as monotherapy in early PD and as adjunctive therapy in advanced PD. In addition, rasagiline has been shown to have neuroprotective effects in in vitro and in vivo studies. The recently completed delayed-start ADAGIO (Attenuation of Disease Progression with Azilect Given Once-daily) trial suggests a potential disease-modifying effect for rasagiline 1 mg/day, though the clinical import of this finding has yet to be established [2]. Rasagiline has been found to be well tolerated and effective in the treatment of early PD and as adjunctive treatment in motor fluctuations. Whether rasagiline is associated with clinically significant neuroprotection (ie, disease modification) in PD is the subject of ongoing clinical trials [3].<br></p>


Catalog Number I001397
CAS Number 136236-51-6
Synonyms

Azilect®

Molecular Formula C12H13N
Purity ≥95%
Target Monoamine Oxidase (MAO)-B
Solubility 10mM in water
Storage -20°C
InChIKey RUOKEQAAGRXIBM-GFCCVEGCSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Weinreb, O., et al., Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog Neurobiol, 2010. 92(3): p. 330-44.

<br>[2]. Leegwater-Kim, J. and E. Bortan, The role of rasagiline in the treatment of Parkinson/’s disease. Clin Interv Aging, 2010. 5: p. 149-56.

<br>[3]. Chen, J.J., D.M. Swope, and K. Dashtipour, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson/’s disease. Clin Ther, 2007. 29(9): p. 1825-49.

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