Rasagiline mesylate

• CAT Number: A001151
• CAS Number: 161735-79-1
• Molecular Formula: C₁₂H₁₃N ∙ CH₃SO₃H
• Molecular Weight: 267.34
• Purity: ≥95%
• Synonyms: TVP-1012
• Target: MAO
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• InChI: InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1
• InChIKey: JDBJJCWRXSVHOQ-UTONKHPSSA-N
• SMILES: CS(=O)(=O)O.C#CCNC1CCC2=CC=CC=C12

Rasagiline Mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson/’s disease.Rasagiline inhibits rat brain MAO type B and type A with IC50 of 4.43 nM and 412 nM, respectively. Rasagiline is three to 15 times more potent than selegiline for inhibition of MAO-B in rat brain and liver in vivo on acute and chronic administration, but has similar potency in vitro.Rasagiline ex vivo inhibits MAO in the brain and liver with ED50 of 4.43 nM and 412 nM, respectively.