RB-3

• CAT Number: I035455
• Molecular Formula: C24H20ClN3O2
• Molecular Weight: 417.89
• Purity: 98%
• Synonyms: RB-3; RB3; RB 3
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-isopropyl-1H-pyrrole-2-carboxylic acid
• InChI: InChI=1S/C24H20ClN3O2/c1-12(2)19-21(20-15-9-11-27-18(15)7-6-16(20)25)23(24(29)30)28-22(19)14-4-3-5-17-13(14)8-10-26-17/h3-12,26-28H,1-2H3,(H,29,30)
• InChIKey: IUEFQUANJWCUNT-UHFFFAOYSA-N
• SMILES: O=C(C1=C(C2=C(Cl)C=CC3=C2C=CN3)C(C(C)C)=C(C4=CC=CC5=C4C=CN5)N1)O

RB-3(CAT: I035455) is a novel and selective polycomb repressive complex 1 (PRC1) inhibitor that directly targets the RING1B–BMI1 complex. By disrupting its interaction with nucleosomes, RB-3 effectively reduces global histone H2A ubiquitination (H2AK119ub), a key epigenetic modification involved in gene silencing. This disruption leads to the reactivation of differentiation pathways and suppresses self-renewal in acute myeloid leukemia (AML) cells. RB-3 shows significant potential in oncology research, particularly in studying epigenetic regulation of cancer and developing targeted therapies for leukemia by promoting the differentiation and apoptosis of malignant cells.