For research use only. Not for therapeutic Use.
RB-3(CAT: I035455) is a novel and selective polycomb repressive complex 1 (PRC1) inhibitor that directly targets the RING1B–BMI1 complex. By disrupting its interaction with nucleosomes, RB-3 effectively reduces global histone H2A ubiquitination (H2AK119ub), a key epigenetic modification involved in gene silencing. This disruption leads to the reactivation of differentiation pathways and suppresses self-renewal in acute myeloid leukemia (AML) cells. RB-3 shows significant potential in oncology research, particularly in studying epigenetic regulation of cancer and developing targeted therapies for leukemia by promoting the differentiation and apoptosis of malignant cells.
| Synonyms | RB-3; RB3; RB 3; |
| Molecular Formula | C24H20ClN3O2 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-(5-chloro-1H-indol-4-yl)-5-(1H-indol-4-yl)-4-isopropyl-1H-pyrrole-2-carboxylic acid |
| InChI | InChI=1S/C24H20ClN3O2/c1-12(2)19-21(20-15-9-11-27-18(15)7-6-16(20)25)23(24(29)30)28-22(19)14-4-3-5-17-13(14)8-10-26-17/h3-12,26-28H,1-2H3,(H,29,30) |
| InChIKey | IUEFQUANJWCUNT-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(C2=C(Cl)C=CC3=C2C=CN3)C(C(C)C)=C(C4=CC=CC5=C4C=CN5)N1)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
