For research use only. Not for therapeutic Use.
Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].
| Catalog Number | I014662 |
| CAS Number | 2032282-97-4 |
| Synonyms | 7-bromo-3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole |
| Molecular Formula | C13H11BrN4S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H11BrN4S/c1-7(2)6-19-13-16-12-11(17-18-13)9-4-3-8(14)5-10(9)15-12/h3-5H,1,6H2,2H3,(H,15,16,18) |
| InChIKey | OVDAOBDZJJZJMY-UHFFFAOYSA-N |
| SMILES | CC(=C)CSC1=NC2=C(C3=C(N2)C=C(C=C3)Br)N=N1 |
| Reference | [1]. Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14. |
