RBN-2397

• CAT Number: I015479
• CAS Number: 2381037-82-5
• Molecular Formula: C₂₀H₂₃F₆N₇O₃
• Molecular Weight: 523.43
• Purity: ≥95%
• Target: Epigenetics

RBN-2397(CAT: I015479) stands as a notable compound in the realm of pharmaceutical and medicinal chemistry. Operating as a potent, orally active inhibitor, RBN-2397 is NAD+-competitive and showcases remarkable selectivity and affinity for PARP7 (Kd=0.001 μM). This unique profile renders it an important candidate for exploring advanced or metastatic solid tumors, as it restores interferon (IFN) signaling. Its capability to bind selectively to PARP7 (IC50<3 nM) positions it as a key tool in molecular studies, offering insights into PARP7-associated mechanisms. RBN-2397’s potential to modulate IFN signaling holds promise for innovative therapeutic strategies against challenging malignancies.

Reference

[1]. RBN-2397-Inhibiting PARP7, a Key monoPARP Cancer Dependency[2]. Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor Targeting a Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.