RBN-3143

For research use only. Not for therapeutic Use.

  • CAT Number: I042293
  • CAS Number: 2360853-16-1
  • Molecular Formula: C22H28FN3O4S
  • Molecular Weight: 449.54
  • Purity: ≥95%
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RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation[1].
RBN-3143 (5 μg; intranasal administration) can improve steroid-resistant asthma mouse models[1].


Catalog Number I042293
CAS Number 2360853-16-1
Synonyms

7-[(1-acetylpiperidin-4-yl)methoxy]-5-fluoro-2-(oxan-4-ylsulfanylmethyl)-3H-quinazolin-4-one

Molecular Formula C22H28FN3O4S
Purity ≥95%
InChI InChI=1S/C22H28FN3O4S/c1-14(27)26-6-2-15(3-7-26)12-30-16-10-18(23)21-19(11-16)24-20(25-22(21)28)13-31-17-4-8-29-9-5-17/h10-11,15,17H,2-9,12-13H2,1H3,(H,24,25,28)
InChIKey LLXIEISWIFSUBQ-UHFFFAOYSA-N
SMILES CC(=O)N1CCC(CC1)COC2=CC3=C(C(=C2)F)C(=O)NC(=N3)CSC4CCOCC4
Reference

[1]. Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.

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