For research use only. Not for therapeutic Use.
RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1].
RIN1 inhibits the proliferation of hematologic cancer cell lines and promoted skeletal muscle diferentiation from C2C12 myoblasts[1].
RIN1 (0.6 μM, corresponding to 3 × IC50) decreases the number of MHC+ cells and increased the number of nuclei per cell, indicating that it induces the formation of multinucleated myofbers[1].
| Catalog Number | I044668 |
| CAS Number | 2682114-39-0 |
| Synonyms | 2-(2-fluorophenoxy)-4-(2-methylpyrazol-3-yl)benzamide |
| Molecular Formula | C17H14FN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H14FN3O2/c1-21-14(8-9-20-21)11-6-7-12(17(19)22)16(10-11)23-15-5-3-2-4-13(15)18/h2-10H,1H3,(H2,19,22) |
| InChIKey | MFSSHRCJKRDIOL-UHFFFAOYSA-N |
| SMILES | CN1C(=CC=N1)C2=CC(=C(C=C2)C(=O)N)OC3=CC=CC=C3F |
| Reference | [1]. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811. |
