For research use only. Not for therapeutic Use.
RDEA-806（Cat No.:I008991）is a selective inhibitor of the enzyme inducible nitric oxide synthase (iNOS), which plays a key role in producing nitric oxide in the body. Nitric oxide is involved in various physiological processes, including immune responses and vasodilation. RDEA-806 has been investigated for its potential therapeutic effects in conditions associated with excessive iNOS activity, such as inflammatory diseases, neurodegenerative disorders, and certain cardiovascular conditions. Preclinical studies suggest that RDEA-806 may help reduce inflammation and tissue damage. However, further clinical trials are needed to evaluate its safety, efficacy, and therapeutic potential in humans.
| Catalog Number | I008991 |
| CAS Number | 1004523-72-1 |
| Synonyms | VRX-806; VRX 806; VRX806; AR-806; AR 806; AR806; RDEA-806; RDEA 806; RDEA806.;4-(2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetamido)-3-chlorobenzoic acid |
| Molecular Formula | C24H18BrClN4O3S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 4-[[2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]-3-chlorobenzoic acid |
| InChI | InChI=1S/C24H18BrClN4O3S/c25-23-28-29-24(34-12-21(31)27-19-9-7-14(22(32)33)11-18(19)26)30(23)20-10-8-15(13-5-6-13)16-3-1-2-4-17(16)20/h1-4,7-11,13H,5-6,12H2,(H,27,31)(H,32,33) |
| InChIKey | MPNGLQDRSJNLPL-UHFFFAOYSA-N |
| SMILES | C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)NC5=C(C=C(C=C5)C(=O)O)Cl |
| Reference | </br>1:Li W, Li X, De Clercq E, Zhan P, Liu X. Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif. Eur J Med Chem. 2015 Sep 18;102:167-79. doi: 10.1016/j.ejmech.2015.07.043. Epub 2015 Jul 26. Review. PubMed PMID: 26276432.</br>2:Usach I, Melis V, Peris JE. Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability. J Int AIDS Soc. 2013 Sep 4;16:1-14. doi: 10.7448/IAS.16.1.18567. Review. PubMed PMID: 24008177; PubMed Central PMCID: PMC3764307. |
