For research use only. Not for therapeutic Use.
RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase[1].
RDR 02308 (0-10 μM; 1 h) inhibits LPS (HY-D1056)-mediated IL-6 production in RAW264.7 cells[1].
| Catalog Number | I041271 |
| CAS Number | 4155-82-2 |
| Synonyms | 3-(furan-2-yl)-5-(4-nitrophenyl)-2-phenyl-3,4-dihydropyrazole |
| Molecular Formula | C19H15N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H15N3O3/c23-22(24)16-10-8-14(9-11-16)17-13-18(19-7-4-12-25-19)21(20-17)15-5-2-1-3-6-15/h1-12,18H,13H2 |
| InChIKey | DCFSIJLWXJXSQC-UHFFFAOYSA-N |
| SMILES | C1C(N(N=C1C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=CC=C3)C4=CC=CO4 |
| Reference | [1]. Lee HK, et al. Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors. Mol Pharmacol. 2007 Oct;72(4):868-75. |
