Regorafenib

For research use only. Not for therapeutic Use.

  • CAT Number: A000931
  • CAS Number: 755037-03-7
  • Molecular Formula: C₂₁H₁₅ClF₄N₄O₃
  • Molecular Weight: 482.81
  • Purity: ≥95%
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Regorafenib(Cat No.:A000931)is a multi-targeted tyrosine kinase inhibitor that blocks various receptors involved in tumor growth, angiogenesis, and metastasis, including VEGFR, PDGFR, and RAF kinases. It is approved for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma. By inhibiting these signaling pathways, regorafenib disrupts cancer cell proliferation and reduces blood vessel formation, ultimately slowing tumor progression. Its broad activity across multiple targets makes it an effective option for patients with advanced cancers, especially those resistant to other therapies.


Catalog Number A000931
CAS Number 755037-03-7
Synonyms

Fluoro-Sorafenib

Molecular Formula C₂₁H₁₅ClF₄N₄O₃
Purity ≥95%
Target c-RET
Solubility >25mg/mL in DMSO
Storage 3 years -20C powder
IUPAC Name 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
InChI InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey FNHKPVJBJVTLMP-UHFFFAOYSA-N
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
Reference

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