Relacorilant

• CAT Number: I008996
• CAS Number: 1496510-51-0
• Molecular Formula: C27H22F4N6O3S
• Molecular Weight: 586.56
• Purity: ≥95%
• Synonyms: [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
• InChI: InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1
• InChIKey: WANIDIGFXJFFEL-SANMLTNESA-N
• SMILES: CN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(CC3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F

Relacorilant is a selective glucocorticoid receptor modulator (SGRM) under investigation for treating conditions associated with hypercortisolism, such as Cushing’s syndrome. Unlike traditional glucocorticoid receptor antagonists, Relacorilant selectively modulates the receptor without affecting the mineralocorticoid receptor, potentially reducing side effects like hypertension. It aims to counteract the harmful effects of excessive cortisol while preserving the beneficial anti-inflammatory actions. Relacorilant is being studied for its efficacy in managing the symptoms of Cushing’s syndrome and related disorders.