For research use only. Not for therapeutic Use.
Remdesivir nucleoside monophosphate (Cat No.:I015329) is an active metabolite derived from the antiviral drug remdesivir. It serves as a potent inhibitor of viral RNA replication by acting as a viral RNA polymerase inhibitor. Following cellular uptake, remdesivir is metabolized into remdesivir nucleoside monophosphate, which then undergoes further intracellular conversion to the triphosphate form. This active metabolite incorporates itself into the growing viral RNA chain, leading to premature termination and inhibition of viral replication. Remdesivir nucleoside monophosphate is a crucial component contributing to the antiviral efficacy of remdesivir against RNA viruses, including SARS-CoV-2.
| Catalog Number | I015329 |
| CAS Number | 1911578-74-9 |
| Molecular Formula | C₁₂H₁₄N₅O₇P |
| Purity | ≥95% |
| Target | Anti-infection |
| IUPAC Name | [(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate |
| InChI | InChI=1S/C12H14N5O7P/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(24-12)3-23-25(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1 |
| InChIKey | ZBHOHJWLOOFLMW-LTGWCKQJSA-N |
| SMILES | C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)COP(=O)(O)O)O)O)C#N)N |
| Reference | [1]. Byoung Kwon Chun, et al. or treating filoviridae virus infections. US20160122374.<br>[2]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. |
