Remimazolam tosylate

• CAT Number: I048001
• CAS Number: 1425904-79-5
• Molecular Formula: C28H27BrN4O5S
• Molecular Weight: 611.5
• Purity: 98%
• Synonyms: UNII-9J7J08A8LT; 9J7J08A8LT
• Target: glucocorticoid
• Target Protein: UNLWPYSYFQLJSV-LMOVPXPDSA-N
• Appearance: Solid
• IC50: Remimazolam shows high affinity (Ki∼30 nM) for the GABAA receptor
• IUPAC Name: 4-methylbenzenesulfonic acid;methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
• InChI: InChI=1S/C21H19BrN4O2.C7H8O3S/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21;1-6-2-4-7(5-3-6)11(8,9)10/h3-6,8,10-12,17H,7,9H2,1-2H3;2-5H,1H3,(H,8,9,10)/t17-;/m0./s1
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CN=C2N1C3=C(C=C(C=C3)Br)C(=NC2CCC(=O)OC)C4=CC=CC=N4

Remimazolam tosylate (CAS 1425904-79-5) is a water-soluble form of remimazolam, a benzodiazepine derivative with potent sedative and anesthetic properties. Developed for intravenous use, it acts as a GABA-A receptor modulator, facilitating inhibitory neurotransmission. Remimazolam offers rapid onset and offset of action, providing procedural sedation and general anesthesia with a shorter recovery period compared to traditional benzodiazepines. Its unique pharmacokinetic profile, coupled with a reversible antagonism, makes it a valuable option in various medical settings.