For research use only. Not for therapeutic Use.
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Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
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Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
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| Catalog Number | I005642 |
| CAS Number | 949912-58-7 |
| Synonyms | 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile |
| Molecular Formula | C₁₅H₁₄N₄S |
| Purity | ≥95% |
| Target | Histone Acetyltransferase |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| InChI | InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19) |
| InChIKey | XAEJIFARBQJLML-UHFFFAOYSA-N |
| SMILES | C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1 |
| Reference | [1]. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32. |
