For research use only. Not for therapeutic Use.
REN-1189 (Cat.No:I009006) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
| Catalog Number | I009006 |
| CAS Number | 183619-38-7 |
| Synonyms | CPI-1189; REN-1189; REN-1654; CPI1189; REN1189; REN1654; CPI 1189; REN 1189; REN 1654;4-acetamido-N-(tert-butyl)benzamide |
| Molecular Formula | C13H18N2O2 |
| Purity | ≥95% |
| Target | TNF-α |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-acetamido-N-tert-butylbenzamide |
| InChI | InChI=1S/C13H18N2O2/c1-9(16)14-11-7-5-10(6-8-11)12(17)15-13(2,3)4/h5-8H,1-4H3,(H,14,16)(H,15,17) |
| InChIKey | DJKNRCWSXSZACF-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C |
| Reference | </br>1: Müller T. CPI-1189. Centaur. Curr Opin Investig Drugs. 2002 Dec;3(12):1763-7. Review. PubMed PMID: 12528314.</br>2: Clifford DB, McArthur JC, Schifitto G, Kieburtz K, McDermott MP, Letendre S, Cohen BA, Marder K, Ellis RJ, Marra CM; Neurologic AIDS Research Consortium.. A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology. 2002 Nov 26;59(10):1568-73. PubMed PMID: 12451199.</br>3: Bjugstad KB, Flitter WD, Garland WA, Philpot RM, Kirstein CL, Arendash GW. CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex. J Neurovirol. 2000 Dec;6(6):478-91. PubMed PMID: 11175320. |
