For research use only. Not for therapeutic Use.
Repirinast, also known as MY-5116, is a mediator release inhibitor used to treat asthma.
| Catalog Number | R048878 |
| CAS Number | 73080-51-0 |
| Synonyms | 4H-Pyrano[3,2-c]quinoline-2-carboxylic acid, 5,6-dihydro-7,8-dimethyl-4,5-dioxo-, 3-methylbutyl Ester; MY 5116; Romet; |
| Molecular Formula | C20H21NO5 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 3-methylbutyl 7,8-dimethyl-4,5-dioxo-6H-pyrano[3,2-c]quinoline-2-carboxylate |
| InChI | InChI=1S/C20H21NO5/c1-10(2)7-8-25-20(24)15-9-14(22)16-18(26-15)13-6-5-11(3)12(4)17(13)21-19(16)23/h5-6,9-10H,7-8H2,1-4H3,(H,21,23) |
| InChIKey | NFQIAEMCQGTTIR-UHFFFAOYSA-N |
| SMILES | CC1=C(C2=C(C=C1)C3=C(C(=O)C=C(O3)C(=O)OCCC(C)C)C(=O)N2)C |
| Reference | </br>1:Effect of a major metabolite of the antiallergic drug repirinast on phosphodiesterase and adenylate cyclase activities. Yamada N, Arai Y, Funayama K, Kadowaki S, Takahashi K, Umezu K.Arzneimittelforschung. 1995 Jan;45(1):33-5. PMID: 7534459 </br>2:Drug-induced solar urticaria due to repirinast. Kurumaji Y, Shono M.Dermatology. 1994;188(2):117-21. PMID: 8136537 </br>3:Repirinast inhibits antigen-induced early and late pulmonary responses and airway hyperresponsiveness in guinea pigs. Yamada N, Ohgaki M, Muramatsu M.Int Arch Allergy Immunol. 1993;100(4):367-72. PMID: 8386963 </br>4:Effect of food on the pharmacokinetics of the active metabolite of the prodrug repirinast. Schaefer HG, Beermann D, Horstmann R, Wargenau M, Heibel BA, Kuhlmann J.J Pharm Sci. 1993 Jan;82(1):107-9. PMID: 8381486 </br>5:The effect of repirinast on airway responsiveness to methacholine and allergen. Patel PC, Rutherford BC, Lux J, Cockcroft DW.J Allergy Clin Immunol. 1992 Nov;90(5):782-8. PMID: 1331217 </br>6:MY-1250, a major metabolite of the anti-allergic drug repirinast, induces phosphorylation of a 78-kDa protein in rat mast cells. Yamada N, Kadowaki S, Takahashi K, Umezu K.Biochem Pharmacol. 1992 Sep 25;44(6):1211-3. PMID: 1358073 </br>7:Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. Takei M, Endo K, Takahashi K.Br J Pharmacol. 1992 Mar;105(3):587-90. PMID: 1378339 Free PMC Article</br>8:Pharmacokinetics of the active metabolite of the prodrug repirinast in healthy Caucasian volunteers after a single oral dose. Beermann D, Schaefer HG, Wargenau M, Heibel B, Sturm Y, Kuhlmann J.Eur J Clin Pharmacol. 1992;42(3):307-12. PMID: 1315685 </br>9:[The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. Nagata M, Tabe K, Houya I, Kiuchi H, Sakamoto Y, Yamamoto K, Dohi Y.Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Apr;29(4):413-9. Japanese. PMID: 1650860 </br>10:Inhibition of histamine release from rat peritoneal mast cells by MY-1250, an active metabolite of Repirinast (MY-5116). Takei M, Endo K, Takahashi K.Int Arch Allergy Appl Immunol. 1990;93(2-3):237-41. PMID: 1712003 |
