For research use only. Not for therapeutic Use.
Resistomycin（Cat No.:R004317）is a polyketide antibiotic derived from Streptomyces species, known for its antibacterial, antifungal, and antitumor properties. It inhibits bacterial RNA synthesis by targeting RNA polymerase, making it effective against a range of Gram-positive bacteria. Resistomycin also exhibits cytotoxic activity, making it a valuable tool in cancer research. Its unique chemical structure and mechanism of action are of interest in the development of novel antimicrobial and anticancer agents. Additionally, Resistomycin is studied for its role in understanding bacterial secondary metabolism and biosynthetic pathway engineering.
| Catalog Number | R004317 |
| CAS Number | 20004-62-0 |
| Synonyms | 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione |
| Molecular Formula | C22H16O6 |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | 6,10,14,19-tetrahydroxy-4,9,9-trimethylpentacyclo[13.3.1.05,18.08,17.011,16]nonadeca-1(19),3,5,7,10,13,15,17-octaene-2,12-dione |
| InChI | InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,24-25,27-28H,1-3H3 |
| InChIKey | MJKDGCARCYPVQG-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)C2=C(C3=C4C5=C2C1=C(C=C5C(C(=C4C(=O)C=C3O)O)(C)C)O)O |
| Reference | Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Shiono Y. et al. Z Naturforsch. [C] 2002, 57, 923.<br/><br/>3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. Roggo B.E. J. Antibiot. 1994, 47, 136.<br/><br/>Molecular structure of heliomycin, an inhibitor of RNA synthesis. Arora S.K. J. Antibiot. 1985, 38, 113</span></p> |
