For research use only. Not for therapeutic Use.
Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis[1].
Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively[1].ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology[1].
| Catalog Number | I011004 |
| CAS Number | 41307-63-5 |
| Synonyms | 3′,6′-dihydroxyspiro[3-oxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene-4,9′-xanthene]-2-one |
| Molecular Formula | C24H14O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H14O5/c25-14-7-9-17-20(11-14)28-21-12-15(26)8-10-18(21)24(17)19-6-2-4-13-3-1-5-16(22(13)19)23(27)29-24/h1-12,25-26H |
| InChIKey | FTUOFHGOGJGQAB-UHFFFAOYSA-N |
| SMILES | C1=CC2=C3C(=C1)C(=O)OC4(C3=CC=C2)C5=C(C=C(C=C5)O)OC6=C4C=CC(=C6)O |
| Reference | [1]. Hernández Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7. |
