For research use only. Not for therapeutic Use.
RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].
RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].
| Catalog Number | I015279 |
| CAS Number | 2414374-53-9 |
| Synonyms | N-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N’,N’-dimethylpropane-1,3-diamine |
| Molecular Formula | C18H21N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H21N5O2/c1-22(2)8-3-7-19-17-6-9-23-18(21-17)14(11-20-23)13-4-5-15-16(10-13)25-12-24-15/h4-6,9-11H,3,7-8,12H2,1-2H3,(H,19,21) |
| InChIKey | DQYRQFLRDJTHQM-UHFFFAOYSA-N |
| SMILES | CN(C)CCCNC1=NC2=C(C=NN2C=C1)C3=CC4=C(C=C3)OCO4 |
| Reference | [1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505. |
